Effectiveness of nab-paclitaxel versus traditional paclitaxels in the treatment of ovarian cancer

Purpose: To evaluate the effect of four taxane drugs, namely, paclitaxel, docetaxel, paclitaxel liposomes (Lipusu), and nab-paclitaxel (Keaili) on ovarian cancer cells both in vivo vitro.
 Methods: BALB/c-nu/nu female mice were used to develop mouse xenograft models. The randomized 5 groups (4 each group), control (PBS) group, docetaxel liposomal group group. drugs determined via cell proliferation toxicity tests. Mouse models employed assess efficacy inhibiting tumor growth.
 Results: Nab-paclitaxel has a significant growth-reducing vitro. In vivo, no differences observed volume among (p < 0.05). produced lowest animal when compared with other three as nab- treatment showed alterations body weight Hematoxylin eosin (H & E) staining revealed degree liver tissue damage treated administered paclitaxels.
 Conclusion: is more effective than traditional paclitaxels. Thus, it promises offer viable alternative first- line chemotherapy for epithelial humans, low systemic fewer hypersensitivity reactions. However, further investigations, including clinical trials are required.